|
KMID : 0191120170320101708
|
|
Journal of Korean Medical Science
2017 Volume.32 No. 10 p.1708 ~ p.1712
|
|
|
Intramyocardial Injection of Stem Cells in Pig Myocardial Infarction Model: The First Trial in Korea
|
|
Kim Min-Chul
Kim Yong-Sook
Kang Wan-Seok
Lee Ki-Hong
Cho Mee-Young
Hong Moon-Hwa
Lim Kyung-Seob
Jeong Myung-Ho
Ahn Young-Keun
|
|
|
Abstract
|
|
|
|
Although cell therapy is emerged for cardiac repair, its efficacy is modest by intracoronary infusion. Therefore, we established the intramyocardial delivery technique using a left ventricular (LV) mapping system (NOGA® XP) using 18 pigs. After adipose tissue-derived mesenchymal stem cells (ATSCs) were delivered intramyocardially to porcine infarcted heart, LV ejection fraction (EF) was increased, and LV chamber size was decreased. We proved the therapeutic effect of intramyocardial injection of ATSC through a LV mapping system in the porcine model for the first time in Korea. The adoption of this technique may accelerate the translation into a clinical application in the near future.
|
|
|
KEYWORD
|
|
|
Mesenchymal Stem Cell Transplantation, Heart Failure, Myocardial Infarction
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
    
|